Chemical names
17β-hydroxy-17α-methyl-2-oxa-5α-androstan-3-one
Oral Oxandrolone raw description
Oxandrolone is an oral anabolic steroid derived from dihydrotestosterone. It was designed to have a very strong separation of the anabolic and androgenic effect, and no significant estrogenic or progestational activity.
Anabolic steroids description
Anabolic steroids are synthetic derivatives of testosterone, having actions similar to the endogenous male sex hormone testosterone. There is not a complete dissociation of the anabolic versus androgen action. Anabolic steroids may suppress gonadotrophic function of the pituitary and may also have a direct effect on the testes.
During exogenous administration of anabolic steroids and androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). With large doses, spermatogenesis may be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH). The actions of anabolic steroids are similar to male sex hormones.
Anabolic steroids may cause growth disturbances and induce premature sexual development if administered to young children. Anabolic steroid hormones may increase low-density lipoproteins (LDL) and decrease high density lipoproteins (HDL). Lipids levels generally return to normal upon discontinuation of treatment. In a single dose pharmacokinetic study of oxandrolone in geriatric subjects, the average elimination half-life was 13.3 hours.
In a similar pharmacokinetic study in younger subjects, the average elimination half-life was 10.4 hours. No significant differences between geriatric and younger test subjects were found for time to peak absorption, peak plasma concentration, or AUC after a single dose. The correlation between plasma level and therapeutic effect has not yet been established.
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