Exemestane Powder

Exemestane Powder

Exemestane Aromasin is an aromatase inhibitor. It works by lowering the amount of estrogen (natural female hormone) produced in the body. This can lower or stop the growth of some breast cancer cells that need estrogen to grow.
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Product Details

Description

Exemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.


Specification

Items

Standard

Results

Description

: White Crystalline Powder

White Powder

Identification

: Positive

Positive

Assay(by HPLC)

: 98.0~102.0%

98.64%

Absorbance(E1cm)

: 465~495

482.5

Melting Point

: 191~195°C

193.5~195.0°C

Loss On Drying

: 0.5%max

0.19%

Specific Rotation

: +288°~ +298°

+290.2°

Residue On Ignition

: 0.1%max

0.03%

Related Substances

: Total:1.5%max

<1.3%


Single:0.5%max

<0.4%

Residue Solvents

: 0.2%max

0.10%

Heavy Metals

: 20PPm max

<10PPm

Conclusion

The specification conform with enterprise standard.

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Application

1. adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to Exemestane for completion of a total of five consecutive years of adjuvant hormonal therapy

2. treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.


Benefits

Exemestane no estrogen rebound, no adverse changes in lipid profiles, increases IGF-1, can actually boost libido on and off cycle, has powerful bloat-reduction effects, lowers SHBG, increasing free test & makes all other anabolic steroids more bio-available, powerful aromatase inhibitor capable of stopping gynecomastia completely on its own.


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