Exemestane Powder CAS 107868-30-4

Exemestane Powder CAS 107868-30-4

CAS: 107868-30-4
MF: C20H24O2
MW: 296.4
Chemical Properties : white to light yellow crystal powder
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Product Details

Description
Exemestane Powder CAS 107868-30-4 is an irreversible steroid aromatase inhibitor. Its structure is similar to that of aromatase’s natural substrate, androstenedione, and acts as a pseudosubstrate. Postmenopausal women’s estrogen is mainly converted from androgen (produced by the adrenal cortex) by aromatase in the surrounding tissue.

Exemestane irreversibly binds with the active site on aromatase to deactivate it, thus dramatically lower estrogen levels in the blood circulation of postmenopausal women.


Specification

TEST ITEMSSPECIFICATIONRESULTS
DescriptionWhite Crystalline PowderWhite Powder
IdentificationPositivePositive
Assay(by HPLC)98.0~102.0%98.64%
Absorbance(E1cm)465~495482.5
Melting Point191~195°C193.5~195.0°C
Loss On Drying0.5%max0.19%
Specific Rotation+288°~ +298°+290.2°
Residue On Ignition0.1%max0.03%
Related SubstancesTotal:1.5%max<1.3%

Single:0.5%max<0.4%
Residue Solvents0.2%max0.10%
Heavy Metals20PPm max<10PPm


Exemestane Powder CAS 107868-30-4


Application
1) By inhibiting aromatase to lower estrogen levels, it can be used to treat hormone-dependent breast cancer in postmenopausal women.

2) Exemestane is suitable for treating advanced breast cancer in naturally or artificially postmenopausal women that has not responded well to tamoxifen treatment. It is also suitable for treating estrogen and progesterone receptor positive postmenopausal advanced breast cancer, and it can also be used to treat metastasized breast cancer and as adjuvant therapy for early breast cancer.


Exemestane Powder


Purchase notes
* Exemestane Powder CAS 107868-30-4 Mini order: 10g
* Price: Negotiated
* Packing: Discreet package or as your request
* Delivery time: Within 24 hours after we confirm the payment
* Payment methods: Western Union, T/T, Bitcoin and MoneyGram
* Reshipment: We will try best to keep parcel safe, and also Warranty ,resending police if the tracking number do not update online or it sezied by customs.

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