Raloxifene Hydrochloride Powder

Raloxifene Hydrochloride Powder

Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits agonistic (estrogenic) activity in bone cells without stimulating ER activity in breast or uterine tissues.
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Product Details

Description

Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women.


Specification

ITEMS

SPECIFICATION

RESULT

Appearance

White &off-white powder

Conform

Loss on drying

≤0.5%

0.4%

Residue on ignition

≤0.1%

0.06%

Solubility

Soluble in 10% sodium hydroxide solution. Slightly Soluble in methanol. Insoluble in water

Conform

Identifications

Infrared Absorption

Conform

Heavy metals

≤10ppm

Conform

Any unspecified individual impurity 2

≤0.10%

Max. 0.08%

Total impurities

≤0.50%

0.40%

Assay

≥98.0%

99.0%

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How Raloxifene hcl works

Raloxifene hcl binds to estrogen receptors on cells, creating a blockade and causing circulating estrogen to take other routes through your body. It slows down normal postmenopausal bone-thinning and increases bone mineral density (BMD). This results in stronger bones and less risk of fractures. An additional benefit of Evista is that it decreases total and LDL cholesterol levels. In breast and uterine tissues, it acts as an estrogen antagonist.


Common Side Effects

nausea; hot flashes; increased perspiration; diarrhea; joint pain; headaches (not migraine)


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